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Mr Nguyen is an overweight 40 year old who has recently been diagnosed with type 2 diabetes. He has been started on Metformin but has been complaining of diarrhoea, some abdominal pain and loss of appetite. He continues to work as a taxi driver and often works the night shift as he has young school aged children. His HbA1c is 8%. The medical staff are considering adding Exenatide to his medication regime.

Outline the mode of action of Metformin and Exenatide and why these drugs may be prescribed together. Describe factors to be considered when administering each of these drugs. 2022 latest  answers