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Pharmacotherapy for Cardiovascular Disorders …heart disease remains the No. 1 killer in America; nearly half of all Americans have high blood pressure, high cholesterol, or smokesome of the leading risk factors for heart disease Murphy et al., 2018 Despite the high mortality rates associated with cardiovascular disorders, improved treatment options do exist that can help address those risk factors that afflict the majority of the population today. As an advanced practice nurse, it is your responsibility to recommend appropriate treatment options for patients with cardiovascular disorders. To ensure the safety and effectiveness of drug therapy, advanced practice nurses must consider aspects that might influence pharmacokinetic and pharmacodynamic processes such as medical history, other drugs currently prescribed, and individual patient factors. Reference: Murphy, S. L., Xu, J., Kochanek, K. D., & Arias, E. (2018). Mortality in the United States, 2017. Retrieved from

TO PREPARE: -Review the Resources for this module and consider the impact of potential pharmacotherapeutics for cardiovascular disorders introduced in the media piece.

Select one the following factors: genetics, gender, ethnicity, age, or behavior factors. -Reflect on how the factor you selected might influence the patients pharmacokinetic and pharmacodynamic processes. -Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patients recommended drug therapy. -Think about how you might improve the patients drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. -Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient.

-Explain how the factor (. genetics, gender, ethnicity, age or behavior) you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned. -Describe how changes in the processes might impact the patients recommended drug therapy. Be specific and provide examples. -Explain how you might improve the patients drug therapy plan and explain why you would make these recommended improvements. Would you discontinue any medications, change the dosage, and/or add medications to the patients regimen? DISCUSS EACH MEDICATION. CASE STUDY ASSIGNED FOR THE ASSIGNMENT: RG has a history of a heart attack at age 54. The patient is diagnosed with hypertension and hyperlipidemia with a recent 10 pound weight gain during COVID-19. Drugs currently prescribed include the following: atorvastatin 80 mg daily lisinopril 40 mg daily metoprolol succinate XL 50 mg daily Repatha 140 mg/ml SC q2weeks (every 2 weeks) aspirin 81 mg loratadine 10mg daily melatonin 10mg qhs (qhs- means at bedtime) omeprazole prn (prn- means as needed) Learning Resources for Advanced pharmacology class Required Readings (click to expand/reduce) Rosenthal, L. D., & Burchum, J. R. (2021). Lehnes pharmacotherapeutics for advanced practice nurses and physician assistants (2nd ed.) St. Louis, MO: Elsevier. Chapter 33, Review of Hemodynamics (pp. 285289) Chapter 37, Diuretics (pp. 290296) Chapter 38, Drugs Acting on the Renin-Angiotensin-Aldosterone System (pp. 297307) Chapter 39, Calcium Channel Blockers (pp. 308312) Chapter 40, Vasodilators (pp. 313317) Chapter 41, Drugs for Hypertension (pp. 316324) Chapter 42, Drugs for Heart Failure (pp. 325336) Chapter 43, Antidysrhythmic Drugs (pp. 337348) Chapter 44, Prophylaxis of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol and Triglyceride Levels (pp. 349363) Chapter 45, Drugs for Angina Pectoris (pp. 364371) Chapter 46, Anticoagulant and Antiplatelet Drugs (pp. 372388) Required Media (click to expand/reduce) Cardiovascular Disorders Meet Dr. Norbert Myslinski as he discusses ACE inhibitors, angiotensin inhibitors, beta-blockers, calcium channel blockers, and diuretics as different categories of hypertension drugs. What potential drugs might be best recommended for patients suffering from hypertension? (8m)

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